Document 2942
 DOCN  M94A2942
 TI    First HIV-1 positive diagnosis coincident with AIDS: presentation and
       prognosis.
 DT    9412
 AU    Poznansky MC; Coker R; Skinner C; Bailey S; Renton A; Weber J; St Mary's
       Hospital, London, U.K.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):19 (abstract no. 051B). Unique
       Identifier : AIDSLINE ICA10/94369633
 AB    OBJECTIVE: Between January 1991 and December 1992, 61/281 (22%) of the
       patients presenting with their first AIDS defining illness to the
       Genito-Urinary Medicine Dept. at St Mary's Hospital in London had not
       previously been diagnosed as being HIV-1 positive. This study sought to
       determine whether late presenters with HIV-1 infection and AIDS (Group
       B) differed from patients who tested HIV-1 positive within the previous
       8 years, and who were followed up in out-patient clinics prior to
       developing AIDS (Group A). METHODS: The clinical details, haematological
       and immunological parameters and survival of patients from the time of
       their first AIDS defining illness were noted. RESULTS: The spectrum of
       first AIDS defining illnesses in the two groups was similar with the
       exception of extra-pulmonary TB which was more common in Group B. The
       two groups did not differ in age, sex, risk factors for HIV-1 infection,
       nationality, county of origin or relevant haematological parameters and
       CD4-positive lymphocyte count determined at the time of the first AIDS
       defining illness. There was no significant difference between the
       proportion of patients in each group who died within 6, 12 and 24 months
       of their AIDS diagnosis. DISCUSSION: Late presenters progress from
       asymptomatic HIV infection to AIDS in the absence of health advice and
       without anti-retroviral drugs or PCP prophylaxis. These patients
       challenge the epidemiological control of HIV-1 and generate new
       questions concerning the impact of early intervention for HIV-1
       infection, in relation to survival after their first AIDS defining
       illness.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY/  MORTALITY
       Adult  Antiviral Agents/THERAPEUTIC USE  Female  Human  HIV
       Infections/*DIAGNOSIS/MICROBIOLOGY  *HIV-1  Male  Prognosis  Time
       Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).